Tissue Classifier
Tissue Classifier Add-on
Product Overview
The Tissue Classifier Add-on utilizes a state-of-the-art machine learning algorithm to identify tissue types based on color, texture, and contextual features. Utilizing a “learn-by-example” approach, the user highlights a few distinct tissue types and within seconds the software learns to categorize tissue. The tissue classifier add-on module runs within/ is embedded in the HALO platform and can be used in conjunction with any of our cell-based analysis modules for BF or FL analysis, ultimately minimizing manual outlining of regions of interest.
To learn more, watch this short demonstration below to see how the tissue classifier can be trained to identify tumor regions for subsequent IHC analysis.
The Tissue Classifier Add-on integrates seamlessly into the HALO™ platform which is compatible with a number of file formats.
Contact info@indicalab.com for product demonstration and pricing information or upload some images for a free trial.
Tissue Classifier Add-on
The Tissue Classifier Add-on utilizes a state-of-the-art machine learning algorithm to identify tissue types based on color, texture, and contextual features. Utilizing a “learn-by-example” approach, the user highlights a few distinct tissue types and within seconds the software learns to categorize tissue. The tissue classifier add-on module runs within/ is embedded in the HALO platform and can be used in conjunction with any of our cell-based analysis modules for BF or FL analysis, ultimately minimizing manual outlining of regions of interest.
To learn more, watch this short demonstration below to see how the tissue classifier can be trained to identify tumor regions for subsequent IHC analysis.
HALO is compatible with a broad spectrum of image and digital slide formats. Yours not on the list? Email us your requirements.
Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Philips (Requires Philips IMS)
Here are a few publications that cite the use of our HALO Tissue Classifier Add-on. Your publication not on the list? Drop us an email to let us know about it!
| Title | Authors | Year | Journal | Application | HALO Modules |
|---|---|---|---|---|---|
| Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study | Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL | 2017 | Laboratory Invesigations | Oncology | Classifier, Cytonuclear |
| The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice | AS Peretti, D Dominguez, MM Grimes, HJ Hathaway, ER Prossnitz, MR Rivera, A Wandinger-Ness, D Kusewitt, LG Hudson | 2017 | The American Journal of Pathology | Oncology | Classifier, Area Quantification, Cytonuclear |
| Islet amyloidosis in a child with type 1 diabetes | Beery ML, Jacobsen LM, Atkinson MA, Butler AE, Campbell-Thompson M | 2019 | Islets | Metabolism | Classifier |
| Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus Macaques | Blair RV, Vaccari M, Doyle-Meyers LA, Roy CJ, Russell-Lodrigue K, Fahlberg M, Monjure CJ, Beddingfield B, Plante KS, Plante JA, Weaver SC, Qin X, Midkiff CC, Lehmicke G, Golden N, Threeton B, Penney T, Allers C, Barnes MB, Pattison M, Datta PK, Maness NJ, Birnbaum A, Fischer T, Bohm RP, Rappaport J | 2020 | The American Journal of Pathology | Infectious Disease | Classifier |
| Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies | Brocato TA, Brown-Glaberman U, Wang Z, Selwyn RG, Wilson CM, Wyckoff EF, Lomo LC, Saline JL, Hooda-Nehra A, Pasqualini R, Arap W, Brinker CJ, Cristini V | 2019 | JCI Insight | Oncology | Classifier |
| Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer | Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S | 2017 | PLOS One | Oncology | Classifier, Cytonuclear |
| Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders | Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, Lee EB, Lee VM-Y, Grossman M, Trojanowski JQ, Irwin DJ | 2019 | Annals of Neurology | Neuroscience | Classifier, Area Quantification, |
| RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer | Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN,Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan O, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O’Connor MJ, Balmaña J, SerraV | 2018 | Annals of Oncology | Oncology | Classifier, Cytonuclear |
| Tumor vessel normalization, immuno-stimulatory reprogramming, and improved survival in glioblastoma with combined inhibition of PD-1, angiopoietin-2, and VEGF | Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y | 2020 | Cancer Immunology Research | Oncology, Immuno-oncology | Classifier, Cytonuclear |
| The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models | Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M | 2018 | Science Advances | Oncology, Neuroscience | Classifier, Cytonuclear |
| Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity | Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Grønbæk K, Olsson R, Ek F, Jerkeman M, Ek S | 2018 | BMC Cancer | Oncology | Classifier, Cytonuclear |
| Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer | Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, Greer PA, Kiefer F, Day AG, Madarnas Y, SenGupta S, Elliott BE | 2019 | Breast Cancer Research | Oncology | Classifier, Cytonuclear |
| Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration | Giorgetti E, Obrecht M, Ronco M, Panesar M, Lambert C, Accart N, Doelemeyer A, Nash M, Bidinosti M, Beckmann N | 2019 | Scientific Reports | Neuroscience | Classifier |
| Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units | Giorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M | 2019 | Cell Reports | Neuroscience | Classifier, Cytonuclear |
| The novel ATM inhbitior (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan montherapy | Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ | 2018 | Oncotarget | Oncology | Classifier, Area Quantification, Cytonuclear |
| MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer | Greer YE, Gilbert SF, Gril B, Narwal R, Brooks DLP, Tice DA, Steeg PS, Lipkowitz | 2019 | Breast Cancer Research | Oncology | Classifier |
| Ultrasensitive automated RNA in situ hybridization for kappa and lambda light chain mRNA detects B-cell clonality in tissue biopsies with performance comparable or superior to flow cytometry | Guo L, Wang Z, Anderson CA, Doolittle E, Kernag S, Cotta CV, Ondrejka SL, Ma X-J, Cook JR | 2018 | Modern Pathology | Classifier | |
| A Phase II Trial of Dovitinib in BCD-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Over-Expression: Hoosier Cancer Research Network Trial HCRN 12-157 | Hahn NH, Bivalacqua TJ, Ross AE, Netto GJ, Baras AS, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, Kyle McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RA, Reed A, Turner SA, de Abreu FB, Gallagher TL, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM | 2016 | Clinical Cancer Research | Oncology | Classifier, Cytonuclear |
| cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma | He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, and Huang J | 2017 | Stem Cell Reports | Oncology | Classifier |
| A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer | Hesterberg AB, Rios BL, Wolf EM, Tubbs C, Wong HY, Schaffer KR, Lotan TL, Giannico GA, Gordetsky JB, Hurley PJ | 2021 | Journal of Pathology:Clinical Research | Oncology | Classifier, ISH/FISH |
| Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer‚ÄîJust About Ready for Prime-Time? | Hofman P, Badoual C, Henderson F, Berland L, Hamila M, Long-Mira E, Lassalle S, Roussel H, Hofman V, Tartour E, Ilié M | 2019 | Cancers | Oncology, Immuno-oncology, Review | Classifier, Multiplex IHC |
| Quantification of histopathological findings using a novel image analysis platform | Horai Y, Mizukawa M, Nishina H, Nishikawa S, Ono Y, Takemoto K, Baba N | 2019 | Journal of Toxicologic Pathology | Toxicology | Classifier |
| Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase | Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A | 2018 | Cancers | Review | Classifier, Cytonuclear, Figure Maker |
| Molecular and functional heterogeneity of cancer associated fibroblasts in high-grade serous ovarian cancer | Hussain A, Voisin V, Poon S, Dmytryshyn J ,Richman C, Meens J, Ho VW, Tang KH, Paterson J, Clarke B, Bernardini M, Bader G, Neel B, Ailles L | 2019 | bioRxiv | Oncology | Classifier, Area Quantification |
| Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21 | Hussain A, Voisin V, Poon S, Karamboulas C, Bui NHB, Meens J, Dmtryshyn J, Ho VW, Tang KH, Paterson J, Clarke BA, Bernardini MQ, Bader GD, Neel BG,4 Ailles LE | 2020 | Journal of Experimental Medicine | Oncology | Classifier, Area Quantification, |
| Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment | Hysi E, Fadhel MN, Wang Y, Sebastian JA, Giles A, Czarnota GJ, Exner AA, Kolios MC | 2020 | Photoacoustics | Other | Classifier, Area Quantification, Object Colocalization |
| pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry | Jones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Carrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ | 2018 | British Journal of Cancer | Oncology | Classifier, Cytonuclear |
| Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC | Kargl J, Zhu X, Zhang H, Yang GHY, Friesen TJ, Shipley M, Maeda DY, Zebala JA, McKay-Fleisch J, Meredith G, Mashadi-Hossein A, Baik C, Pierce RH, Redman MW, Thompson JC, Albelda SM, Bolouri H, Houghton AM | 2019 | JCI Insight | Immuno-oncology | Classifier, Highplex FL |
| DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect | Kim T, Tafoya E, Chelliah MP, Lekwuttikarn R, Li J, Sarin KY, Teng J | 2017 | Developmental Biology | Myology | Classifier, Area Quantification |
| Digital image analysis improves precision of PD‐L1 scoring in cutaneous melanoma | Koelzer VH, Gisler A, Hanhart JC, Griss J, Wagner SN, Willi N, Cathomas G, Sachs M, Kempf W, Thommen DS, Mertz KD | 2018 | Histopathology | Oncology, Immuno-oncology | Classifier, Multiplex IHC |
| Precision immunoprofiling by image analysis and artificial intelligence | Koelzer VH, Sirinukunwattana K, Rittscher J, Mertz KD | 2019 | Vichows Archiv | Review | Classifier, Multiplex IHC, Spatial Analysis |
| Machine learning approaches for pathologic diagnosis | Komura D, Ishikawa S | 2019 | Vichows Archiv | Review | Classifier, HALO AI |
| Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter‑platform agreement | Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B | 2018 | Breast Cancer Research and Treatment | Oncology | Classifier, Cytonuclear |
| Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism | Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A | 2021 | bioRxiv | Oncology | Classifier, Cytonuclear |
| Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation | Ku TJY, Ribeiero RVP, Ferreira VH, Galasso M, Keshavjee S, Kumar D, Cypel M, Humar A | 2020 | EBioMedicine | Other | Classifier, Cytonuclear |
| Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma | Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, Herlin P, Laurinaviciene A, Muftah AAA, Miligy I, Aleskandarany M, Rakha EA, Green AR, Ellis IO | 2016 | Virchows Archiv | Oncology | Classifier, Cytonuclear |
| An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes | Levet S, Medina J, Joanou J, Demolder A, Queruel N, Réant K, Normand M, Seffals M, Dimier J, Germi R, Piofczyk T, Portoukalian J, Touraine J-L, Perron H | 2017 | JCI Insight | Immunology, Metabolism | Classifier, Cytonuclear |
| Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival | Logsdon DP, Fenil S, Fabrizio C, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML | 2018 | Scientific Reports | Oncology | Classifier, Cytonuclear |
| Implementation of PD-L1 22C3 IHC pharmDxTM in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® Prefixation | Lou SK, Ko HM, Kinoshita T, MacDonald S, Weiss J, Czarnecka-Kujawa K, Boerner SL, Yasufuku K, Tsao M-S, Schwock J | 2020 | Acta Cytologica | Oncology | Classifier, Membrane |
| Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer | Martin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W | 2019 | BMC Cancer | Oncology | Classifier, Cytonuclear |
| Prognostic value of tumor-inltrating immune cells in primary colorectal cancer and metastases | Martin SZ, Tagscherer KE, Deckert S, Horst D, Moehler M, Lang H, Roth W | 2020 | *Pre-Print | Immuno-oncology | Classifier, Cytonuclear |
| MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory study | McIntyre JB, Ko JJ, Siever J, Chan AMY, Simpson RHW, Hao D, Lau HY | 2019 | Diagnostic Pathology | Oncology | Classifier, Highplex FL |
| A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea | Morales-Loredo H, Jones DT, Barrera A, Mendiola P, Garcia J, Pace CE, Murphy M, Kanagy NL, Gonzalez Bosc LV | 2019 | Renal Pathology | Metabolism | Classifier, Cytonuclear, Figure Maker |
| Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patients | Nearchou IP, Gwyther BM, Georgiakakis ECT, Gavriel CG, Kajiwara Y, Ueno H, Harrison DJ, Caie PD | 2020 | Digital Medicine | Immuno-oncology | Classifier, Area Quantification, Spatial Analysis |
| Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status | Nestarenkaite A, Fadhil W, Ramusson A, Susanti S, Hadjimichael E, Laurinaviciene A, Ilyas M, Laurinavicius A | 2020 | Cancers | Immuno-oncology | Classifier, Multiplex IHC |
| Locally confined IFNɣ production by CD4+ T cells provides niches for murine cytomegalovirus 4 replication in the salivary gland | Oderbolz J, Zangger N, Zimmerman L, Sandu I, Starruß J, Graw F, Oxenius A | 2021 | bioRxiv | Classifier, Spatial Analysis, Highplex FL | |
| Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images | Ono A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Oshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T T | 2020 | Cancer Medicine | Classifier, Multiplex IHC, Serial Section | |
| Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations | Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H | 2019 | The Journal of Clinical Endocrinology & Metabolism | Oncology | Classifier, Area Quantification |
| Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer | Osman J, Savari S, Chandrashekar NK, Bellamkonda K, Souglas D, Sjolander A | 2017 | Oncotarget | Oncology, Immunology | Classifier, Area Quantification |
| Mechanical regulation of glycolysis via cytoskeleton architecture | Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G | 2020 | Nature | Oncology | Classifier, Cytonuclear, TMA |
| Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity | Petkevicius K, Virtue S, Bidault G, Jenkins B, Cubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie M, Koulman A, Vidal-Puig A | 2019 | bioRxiv | Classifier, Vacuole | |
| Detection of Lung Cancer Lymph Node Metastases from Whole-Slide Histopathologic Images Using a Two-Step Deep Learning Approach | Pham HHN, Futakuchi M, Bychkov A, Furukawa T, Kuroda K, Fukuoka J | 2019 | The American Journal of Pathology | Oncology | Classifier, HALO AI |
| Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human | Pognan F, Mahl JA, Papoutsi M, David Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek‑Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout S-D, Bouchard P, Trendelenburg C | 2018 | Archives of Toxicology | Toxicology | Classifier, Cytonuclear |
| Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E | 2020 | Gut | Oncology | Classifier, Cytonuclear |
| Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease | Riggs J, Pace C, Ward HH, Gonzalez Bosc L, Rios L, Barrera A, Kanagy NL | 2018 | American Jornal of Physiology-Renal Physiology | Metabolism | Classifier, Cytonuclear |
| p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphoma | Rodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R, Kolstad A, Sundstrom C, Glimelius I, Gronbaek K, Kwiecinska A, Porwit A, Jerkeman M, Ek S | 2020 | British Journal of Haematology | Oncology | Classifier, Cytonuclear |
| Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase Supplementation | Schertz H, Danicke S, Frahm J, Schatzmayr D, Dohnal I, Bichl G, Schwartz-Zimmerman HE, Colicchia S, Breves G, Teifke JP, Kluess J | 2018 | Toxins | Toxicology | Classifier |
| In vivo characterization of a new type of biodegradable starch microsphere for transarterial embolization | Sommer CM, Do TD, Schlett CL, Flechsig P, Gockner TL, Kuthning A, Vollherbst DF, Pereira PL, Kauczor HU, Macher-Göppinger S | 2017 | Journal of Biomaterials Applications | Oncology | Classifier |
| Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma | Stenzel PJ, Schindeldecker M, Teagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S | 2020 | Translational Oncology | Oncology, Immuno-oncology | Classifier, Cytonuclear, TMA |
| A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification | Van Cutsem E, Bang Y-J, Mansoor W, Petty RD, Chao Y, Cunningham D, Ferry DR, N. R. Smith NR, Frewer P, Ratnayake J, Stockman PK, Kilgour E, and Landers D | 2017 | Annals of Oncology | Oncology | Classifier, ISH/FISH |
| Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial | van Dijk N, Gil-Jimenez A, Silina K, Hendricksen K, Smit LA, de Feijter JM, van Montfoort ML, van Rooijen C, Peters D, Broeks A, van der Poel HG, Bruining A, Lubeck Y, Sikorska K, Boellaard TN, Kvistborg P, Vis DJ, Hooijberg E, Schumacher TN, van den Broek M, Wessels LFA, Blank CU, van Rhijn BW, van der Heijden MS | 2020 | Nature Medicine | Immuno-oncology | Classifier |
| SLFN11 informs on standard of care and novel treatments in a wide range of cancer models | Winkler C, Armenia J, Jones GN, Tobalina L, Sale MJ, Petreus T, Baird T, Serra V, Wang AT, Lau A, Garnett MJ, Jaaks P, Coker EA, Pierce AJ, O'Connor MJ, Leo E | 2020 | British Journal of Cancer | Oncology | Classifier, Cytonuclear |
| Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinoma | Young RJ, Bressel M, Porceddu S, Cernelc J, Savas P, Liu H, Urban D, Thai AA, Cooper C, Fua T, Neeson P, Rischin D, Solomon B | 2019 | Oral Oncology | Oncology, Infectious Disease | Classifier, Highplex FL |
| A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats | Tarry-Adkins JL, Aiken CE, Ashmore TJ, Fernandez-Twinn DS, Chen J-H, Ozanne SE | 2018 | The FASEB Journal | Neuroscience, Metabolism | Classifier, Vacuole |
| Impact of pre‐therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV‐specific T‐cell therapy | Walker DG, Shakya R, Morrison B, Neller MA, Matthews KK, Nicholls J, Smith C, Khanna R | 2019 | Clinical & Translational Immunology | Immuno-oncology | Classifier |
| CD38 in Advanced Prostate Cancers | Guo C, Crespo M, Gurel B, Dolling D, Rekowski J, Sharp A, Petremolo A, Sumanasuriya S, Rodrigues DN, Ferreira A, Pereira R, Figueiredo I, Mehra N, Lambros MBK, Neeb A, Gil V, Seed G, Terstappen L, Alimonti A, Drake CG, Yuan W, de Bono JS | 2021 | European Urology | Oncology | Classifier, Highplex FL |
| Activated Regulatory T-Cells, Dysfunctional and SenescentT-Cells Hinder the Immunity in Pancreatic Cancer | Sivakumar S, Abu-Shah E, Ahern DJ, Arbe-Barnes EH, Jainarayanan AK, Mangal N, Reddy S, Rendek A, Easton A, Kurz E, Silva M, Soonawalla Z, Heij LR, Bashford-Rogers R, Middleton MR, DUstin ML | 2021 | cancers | Classifier, Multiplex IHC, Spatial Analysis, Highplex FL | |
| Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma | Kazdal D, Rempel E, Oliveira C, Allgäuer M, Harms A, Singer K, Kohlwes E, Ormanns S, Fink L, Kriegsmann J, Leichsenring M, Kriegsmann K, Stögbauer F, Tavernar L, Leichsenring J, Volckmar A-L, Longuespée R, Winter H, Eichhorn M, Heußel CP, Herth F, Christopoulos P, Reck M, Muley T, Weichert W, Budczies J, Thomas M, Peters S, Warth A, Schirmacher P, Stenzinger A, Kriegsmann M | 2021 | Translational Lung Cancer Research | Oncology | Classifier, Cytonuclear |
| Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells | Newman AC, Falcone M, Uribe AH, Zhang T, Athineos D, Pietzke M, Vazquez A, Blyth K, Maddocks ODK | 2021 | Molecular Cell | Immuno-oncology | Classifier, ISH/FISH |
| TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy | Wei Z, Singh O, Ekinci C, Gill J, Li M, Mamatjan Y, Karimi S, Bunda S, Mansouri S, Aldape K, Zadeh G | 2021 | Acta Neuropathologica Communications | Immunology, Neuroscience | Classifier, Multiplex IHC |
| Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Kim D-K, Bandara G, Cho Y-E, Komarow HD, Donahue DR, Karim B, Baek M-C, Kim HM, Metcalfe DD, Olivera A | 2021 | Nature Communications | Classifier |
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