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Object Colocalization FL

OBJECT COLOCALIZATION FL

 

Product Overview

The Object Colocalization FL module reads multi-channel images, and identifies and counts up to two types of objects. Each object type is detected based on size and shape. The module reports the number of each object type and the percentage of overlapping (co-localizing) area when applicable. Optionally, it is possible to output the complete object data table which includes the following outputs: individual object sizes, overlapping percentages, and intensity measurements for each dye.

In the example above the module identifies both vessels and amyloid plaques in mouse brain. Vessels are marked red, plaques are marked green, and co-localizing regions are marked yellow.

The Object Colocalization FL module integrates seamlessly into the HALO™ platform which is compatible with a number of third party systems and  file formats.

Contact info@indicalab.com for product demonstration and pricing information or upload some images for a free trial.

OBJECT COLOCALIZATION FL

The Object Colocalization FL module reads multi-channel images, and identifies and counts up to two types of objects. Each object type is detected based on size and shape. The module reports the number of each object type and the percentage of overlapping (co-localizing) area when applicable. Optionally, it is possible to output the complete object data table which includes the following outputs: individual object sizes, overlapping percentages, and intensity measurements for each dye.

In the example above the module identifies both vessels and amyloid plaques in mouse brain. Vessels are marked red, plaques are marked green, and co-localizing regions are marked yellow.

HALO is compatible with a broad spectrum of image and digital slide formats.  Yours not on the list? Email us your requirements.

Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Philips (Requires Philips IMS)

Here are a few publications that cite use of the Object Colocalization Brightfield or FL modules.  Your publication not on the list?  Drop us an email to let us know about it!

Title Author Year Journal
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum Kritzingerab A, Ferger B, Gillardon F, Stierstorfer B, Birk G, Kochanek S, Ciossek T 2018 Neurobiology of Aging
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Grønbæk K, Olsson R, Ek F, Jerkeman M, Ek S 2018 BCM Cancer
Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma
Heby M, Lundgren S, Nodin B, Elebro J, Eberhard J, Jirström K
2018 Journal of Translational Medicine
Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer’s disease Cramera PE, Gentzela RC, Tanisb KQ, Vardiganc J, Wanga Y, Connollyd B, Manfree P, Lodgef K, Rengera JJ, Zerbinattia C, Uslaner JM 2017 Neurobiology of Aging
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage Villarreal S, Zhao F, Hyde LA, Holder D, Forest T, Sondey M, Chen X, Sur C, Parker EM, Kennedy ME 2017 Journal of Alzheimer’s Disease
Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade Eichten A, Su J, Adler AP, Zhang L, Ioffe E, Parveen AA, Yancopoulos GD, Rudge J, Lowy I, Lin HC, MacDonald D, Daly C, Duan X, Thurston G 2016 Cancer Research
The Prognostic Impact of NK/NKT Cell Density in Periampullary Adenocarcinoma Differs by Morphological Type and Adjuvant Treatment Lundgren S, Warfvinge CF, Elebro J, Heby M, Nodin B, Krzyzanowska A, Bjartell A, Leandersson K, Eberhard J, Jirstrom K 2016 PLOS ONE
Cerebral Protection During MitraClip Implantation: Initial Experience at 2 Centers Frerker C, Schlüter M, Sanchez OD, Reith S, Romero ME, Ladich E, Schröder J, Schmidt T, Kreidel F, Joner M 2015 JACC: Cardiovascular Interventions
Semi-Automated Digital Image Analysis of Pick’s Disease and TDP-3 Proteinopathy Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ 2015 Journal of Histochemistry & Cytochemistry

Use the form below to upload up to three images for us to analyze using HALO.  If the form does not display, please click here.