Indica
Backed by cutting edge technology, an uncompromising focus on ease-of-use and dedicated customer service, Indica Labs’ software and services are being used to make vital discoveries in pathology labs and research organizations around the world.
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Microglial Activation Quantification

Microglial Activation

 

Product Overview

The Microglial Activation module measures microglia cell activation in brightfield whole slide images and photomicrographs. This module detects microglia, soma, and processes, and ultimately reports the number of activated microglial cells, the number of inactivated microglial cells, and the number of negative (non-microglia) cells detected. In addition to cell classification and counting, this tool precisely measures cell processes. It reports the total process area and length, as well as the average process area, length, and thickness, and quantifies process branching by counting the number of branch points per cell.

In the example shown above, the microglia are identified in brown and all nuclei are counterstained with hematoxylin. Processes are identified in yellow and the cell bodies of activated microglia are in red and inactive or resting microglia are in green.

The Microglial Activation module integrates seamlessly into the HALO™ platform which is compatible with a number of third party systems and  file formats.

Contact info@indicalab.com for product demonstration and pricing information or upload some images for a free trial.

Microglial Activation

The Microglial Activation module measures microglia cell activation in brightfield whole slide images and photomicrographs. This module detects microglia, soma, and processes, and ultimately reports the number of activated microglial cells, the number of inactivated microglial cells, and the number of negative (non-microglia) cells detected. In addition to cell classification and counting, this tool precisely measures cell processes. It reports the total process area and length, as well as the average process area, length, and thickness, and quantifies process branching by counting the number of branch points per cell.

In the example shown above, the microglia are identified in brown and all nuclei are counterstained with hematoxylin. Processes are identified in yellow and the cell bodies of activated microglia are in red and inactive or resting microglia are in green.

HALO is compatible with a broad spectrum of image and digital slide formats.  Yours not on the list? Email us your requirements.

Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Philips (Requires Philips IMS)

Here are a few publications that cite use of our Microglial Activation module.  Your publication not on the list?  Drop us an email to let us know about it!

Title Author Year Journal
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum Kritzingerab A, Ferger B, Gillardon F, Stierstorfer B, Birk G, Kochanek S, Ciossek T 2018 Neurobiology of Aging

Use the form below to upload up to three images for us to analyze using HALO.  If the form does not display, please click here.